Completely unrelated as signs I believe.
Then MonkeyPox, Covid and all of those enhanced viri in labs around the world yet to be released would be part of the 4th Seal/4th Horseman of the Apocalypse:
"When
the Lamb broke the fourth seal, I heard the voice of the fourth living creature saying, “Come!” I looked, and behold, an ashen horse; and the one who sat on it had the name Death, and Hades was following with him. Authority was given to them over a fourth of the earth, to kill with sword, and famine,
and plague, and by the wild animals of the earth." - Revelation 6:7-8
I am not convinced, but there is an interpretation of the 4 horsemen that would indicate the first 4 seals have been broken (with the 1st seal being broken over 1000 years ago).
White Horse would be the Catholic Church (and by extension, religions in general). Thus, the rise of Islam, the Protestant Reformation, the Spanish Missions and even current day missionaries of various religions would be part of this 1st Seal.
Red Horse would be an increase in wars: Revolutionary wars around the world, WWI, WWII, etc.. would all be part of this 2nd Seal.
Black Horse would be Capitalism (and also ultimately Socialism/Communism as we see that eventually it takes a day's wages to buy a loaf of bread).
Pale Horse would be the collapse of civilization due to wars, famines, diseases; death then comes due to this collapse, including eventually wild animal attacks (e.g., modern man not being able to survive in the wild)
Like I said, I'm not convinced, but that may partially be due to my Pre-Trib upbringing that says the 1st Horseman (1st Seal) is the appearance of the Antichrist. Which if this is the case, then none of the seals have yet been broken. While I have abandoned most Pre-Trib beliefs, somehow the 1st Seal being the AC still seems to be legitimate to me.