Another vote for Carlisle. I've run a variety of box store tires over the years, also with good luck but the Carlisle's seem to wear a little better.
Also another vote for extra spares, a 12 ton bottle jack and a cordless impact.
Bebop makes a strong argument. I fell asleep behind the wheel on the way back from Moab one time out in the middle of BFE Illinois, went off the road and it was only the rumble strips waking me up that saved us. We were far enough off into the median that we hit something and blew both driver side tires on my 26' Kaufman trailer with 2 rigs on it.
What a fuckin shit show. Yes we had 2 spares. But with both tires flat, the bottle jack wasn't tall enough to get the frame high enough in the air and the axles were only inches off the ground. So we had to pull the high lift off the Jeep, lift the trailer frame as high as we could with the bottle jack, use the hi lift to help hold the frame up, block the bottle jack again to lift it again. We still couldn't get the axles high enough so we had to use the OEM jack out of the truck to get the axle high enough to get a fresh tire on. So, 2 tires and 3 jacks to get the job done. Then we still had another 7 hours home with no spares.
Cordless impact? Why the fuck would someone NOT carry one when trailering? No explanation needed.
Carrying enough spares to cover one side of a heavily loaded trailer makes sense. So often people don't realize they have a flat and end up wiping out the other tire that is carrying all the load. I carry 3 spares for my tri-axle gooseneck because I know it's possible to blow the whole side.
One other thing that hasn't been mentioned, TPMS's are awesome! I've caught a low tire one of my trailers more than once.