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COVID 19 Treatments Remdesivir

grumpy356

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So shady shit abounds, who would have thought

https://www.nejm.org/doi/full/10.1056/NEJMoa2007764

https://www.thelancet.com/journals/l...022-9/fulltext

Summary

Background

No specific antiviral drug has been proven effective for treatment of patients with severe coronavirus disease 2019 (COVID-19). Remdesivir (GS-5734), a nucleoside analogue prodrug, has inhibitory effects on pathogenic animal and human coronaviruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro, and inhibits Middle East respiratory syndrome coronavirus, SARS-CoV-1, and SARS-CoV-2 replication in animal models.Methods

We did a randomised, double-blind, placebo-controlled, multicentre trial at ten hospitals in Hubei, China. Eligible patients were adults (aged ≥18 years) admitted to hospital with laboratory-confirmed SARS-CoV-2 infection, with an interval from symptom onset to enrolment of 12 days or less, oxygen saturation of 94% or less on room air or a ratio of arterial oxygen partial pressure to fractional inspired oxygen of 300 mm Hg or less, and radiologically confirmed pneumonia. Patients were randomly assigned in a 2:1 ratio to intravenous remdesivir (200 mg on day 1 followed by 100 mg on days 2–10 in single daily infusions) or the same volume of placebo infusions for 10 days. Patients were permitted concomitant use of lopinavir–ritonavir, interferons, and corticosteroids. The primary endpoint was time to clinical improvement up to day 28, defined as the time (in days) from randomisation to the point of a decline of two levels on a six-point ordinal scale of clinical status (from 1=discharged to 6=death) or discharged alive from hospital, whichever came first. Primary analysis was done in the intention-to-treat (ITT) population and safety analysis was done in all patients who started their assigned treatment. This trial is registered with ClinicalTrials.gov, NCT04257656.Findings

Between Feb 6, 2020, and March 12, 2020, 237 patients were enrolled and randomly assigned to a treatment group (158 to remdesivir and 79 to placebo); one patient in the placebo group who withdrew after randomisation was not included in the ITT population. Remdesivir use was not associated with a difference in time to clinical improvement (hazard ratio 1·23 [95% CI 0·87–1·75]). Although not statistically significant, patients receiving remdesivir had a numerically faster time to clinical improvement than those receiving placebo among patients with symptom duration of 10 days or less (hazard ratio 1·52 [0·95–2·43]). Adverse events were reported in 102 (66%) of 155 remdesivir recipients versus 50 (64%) of 78 placebo recipients. Remdesivir was stopped early because of adverse events in 18 (12%) patients versus four (5%) patients who stopped placebo early.Interpretation

In this study of adult patients admitted to hospital for severe COVID-19, remdesivir was not associated with statistically significant clinical benefits. However, the numerical reduction in time to clinical improvement in those treated earlier requires confirmation in larger studies.


https://www.cnn.com/2020/05/22/inves...les/index.html

New York (CNN Business)Moderna's stock price skyrocketed as much as 30% on Monday after the biotech company announced promising early results for its coronavirus vaccine. As ordinary investors piled in, two insiders were quietly heading for the exits.

Moderna's chief financial officer and chief medical officer executed options and sold nearly $30 million of shares combined on Monday and Tuesday, SEC filings reviewed by CNN Business show.
The sales occurred after Moderna (MRNA) excited Wall Street before markets opened Monday by announcing encouraging vaccine trial results. Moderna's market value swelled to $29 billion -- even though the company has no marketed products.
After spiking to as high as $87 on Monday, Moderna's stock price has since retreated below $70 as medical experts have debated the importance of the early findings
 

Slander

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If there arent masses of people in the hospitals in a few days not being able to breathe after these protests kicked off, this entire response was a sham.
 

grumpy356

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And the drug that ther is no money to be made from , hydroxychloroquine

https://internetprotocol.co/hype-new...ion-hcq-works/

In Italy, only 20 out of 65,000 chronic Lupus patients got COVID-19.

Out of an audience of 65,000 chronic patients (Lupus and Rheumatoid Arthritis), who systematically take Plaquenil/hydroxychloroquine, only 20 patients tested positive for the virus. Nobody died, and nobody is in intensive care, according to the data collected so far.
 

grumpy356

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if there arent masses of people in the hospitals in a few days not being able to breathe after these protests kicked off, this entire response was a sham.

exactly
 

dntsdad

Central California
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Best Covid treatment = go about your fucking life UNLESS you have immune issues or elderly. Just like most everything else
 

woods

I can fuck up literally anything.
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Best Covid treatment = go about your fucking life UNLESS you have immune issues or elderly. Just like most everything else

Been saying this all along.

How could you not wear a mask?

Me, or anyone I live with are not high risk.

But what my health?!

Your health and well being is not my responsibility.

YOU'RE AN ASSHOLE

:rolleyes:
 
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swtfman

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If there arent masses of people in the hospitals in a few days not being able to breathe after these protests kicked off, this entire response was a sham.

If this turns out to be true there won't be single peep from the media.
 

Poriggity

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Covid was a complete scam and still is. The riots are also orchestrated but not by BLM like everyone thinks.:rolleyes:
 

Cryptictoy

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Old timer today mention to me that they are paid protesters, by who I don't know ? He mentioned sombody named george.
 
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