I have tons of hours of experience aboard Yamahas. You're going to struggle to find a more dependable bike than Yamaha as far as 450 motocross models are concerned.
I'm going to do a little breakdown on what I know about the brands. This will mostly apply to older carbureted models you'll be able to find on a budget.
Honda: Every 450 and 250 motocross thumper made between 2002 and (debateably) 2010 had issues with valve seats. Valves come out of adjustment and require regular maintenance, eventually bottoming out. Not much experience with the more modern ones, except i rode a 2020 factory edition 450r and that thing was a dream. No reports on reliability since honda lost so much of the market after their engines sucked shit for 10 years.
Kawi: Always known for handling weird. Other than the few years that the 250f was shared with the suzuki rmz, I don't know anything about overall reliability. the 07 KX450f i was in close contact with for a few years seemed to take a beating with no complaints. The 2015ish years had really wacky forks but they ran good. Brand new kawis are really coming into their own, they seem to be sweet bikes.
Suzuki: Fuck suzuki. They shit the bed so hard when the 4 strokes came out I'm basically glad that they're getting ready to pull out of the market. The first 3 years of suzuki RMZ (in both 250 and 450 flavor) had a stupid engineering design flaw around the kick starter idler gear. Cracked crank cases for days. And also those years were a 4 speed on the 450. The bike handled as you would expect from a yellow bike though, and when it was running it ran damn hard for a carbureted bike. That's about all the positive I have to say about it.
Yamaha: Stay away from steel framed 450s. 4 speed trannies aren't worth owning. yz and wr 400s are too outdated and heavy to be worth the hassle. YZ426s are okay, in my opinion not really worth the hype people try to lay onto them.
The 06-09 YZ450f is widely regarded as one of the greatest motocross platforms of all time. They handle good, their suspension is literally still at the forefront of the market to this day, and the yamaha 5 valve engine is as reliable as a rock. Least it was for me over the 200 or so hours I put on one without rebuilding it
my 2015 450f then had just as impeccable of a track record. Took that bike all the way to 260 hours without so much as even breaking the seal on the valve cover. Piston skirts had life left and the valves hadn't moved so much as a thou
Yes, I'm a yamaha fag, sue me.
KTM: KTM was known for being fickle, and expensive to buy parts for until they started really pulling ahead of the market in the early 20 teens. I've never necessarily heard of any common complaints or problems for the early years though, other than frame cracking issues in the early 00's.
Good luck, happy hunting, and report back with what you settle on!